The microbes in the human gastrointestinal tract can exert a strong influence on our bodies, in part by creating and ...

We and others have previously characterized changes in circulating metabolite levels following diet-induced weight loss. Our aim was to investigate whether baseline metabolite levels and ...

Sepsis and severe pneumonia are frequently accompanied by disruption of the gut microbiota, leading to immune dysfunction and ...

Heart disease remains the leading cause of death globally. Factors such as smoking, high blood pressure, obesity and diabetes ...

Early-life gut microbiome-metabolome interactions play a central role in shaping host physiology, with microbially-produced metabolites influencing key biological processes. However, studying these ...

The accumulation of the metabolite fumarate in the mitochondrion, the powerhouse of a cell, can cause inflammation associated with diseases such as cancer and autoimmune diseases. A new study shows ...

Northwestern Medicine investigators have identified a surprising culprit in the progression of inflammatory bowel disease: a naturally occurring metabolic compound in the gut, according to a study ...